Music and architecture: a composer’s perspective on form, process and product

This portfolio consists of fourteen compositions: 1. on hearing light fall (piano sextet) 2. Woven Palaces (saxophone quartet) 3. Piranesi’s Fantasies (solo piano) 4. Portrait of Marinela (8 players) 5. Hora Spoitorilor (solo viola) 6. de stamparare (solo oboe) 7. Fantasia on theme of Marinela (solo piano) 8. Caught on the Corner (wind quartet) 9. A Body is a Body is a Body Even So (SSAATTBB acapella) 10. Proprioception (symphony orchestra) 11. Nacre Voit (string quartet and trumpet) 12. Cantec Tesute (14 players) 13. Ikon (solo clarinet) 14. Traffick – excerpts: Sc.1 Mother(s) and Daughter(s) // Sc. 2 Road Kill (chamber opera) In these pieces I explore a variety of compositional processes and show how I aim find a rationale to realise a poetic, abstract architectural idea. Whilst there are a variety of separate ‘leitmotifs’ in my output there is a clear distinction between both the technical and expressive concerns that results in a hierarchical level in the compositional process. The larger-scale, structure-specific translation of architectural spaces into my musical composition is of paramount importance whilst my interest in the trumpet timbre and a particular anonymous Romanian folk theme Hora Spoitorilor are material-specific, creative springboards and used more intuitively. The more technical ‘environmental’ concerns are a method for organising the intuitive use of particular sonorities and the melodic and rhythmic qualities of the folk tune. Modern art and architecture deals with the sensuous relationship between space and artistic experience as well as the notion of drawing a concept of space into the work itself, not just symbolically, but experientially. In a similar way I draw on particular sonorities of the trumpet timbre, and the instrument’s associations with light, by mapping these sensuous associations to my treatment of, and appreciation of, its sound whilst still continuously focusing on architectural ideas as subjective metaphors in my work. Although each piece does prescribe its own terms, in-as-much that it stands in its own right, this thesis will look at the role of the pieces as ‘satellite’ works surrounding the final work Traffick. My in-depth research into particular sonorities, harmonic progressions, orchestration, and augmentation and diminution of rhythmic devices are all compositional processes that have informed my writing in Traffick. Each piece is also contextualised with other works of art and artistic ideas. This exchange is sometimes with painting or sculpture but most importantly for this work with architecture and philosophical writings on architecture

Promoting inclusion oral-health:social interventions to reduce oral health inequities

The aim of this collection of papers is to provide the reader with a cogent understanding of the role of evidence in the development of social or community-based interventions to promote inclusion oral-health and reduce oral health, health, and psychosocial inequities. In addition, this material will include various methods used for their implementation and evaluation. At the outset, the reader will be offered a working definition of inclusion oral-health, which will be modelled on the work of Luchenski et al. [1]. The interventions described are theoretically underpinned by a pluralistic definition of evidence-based practice [2] and the radical discourse of health promotion as postulated by Laverack and Labonte [3] and others [4,5]. This Special Issue will consist of eight papers, including an introduction. The first three papers will examine the various sources of evidence used to transform top-down into bottom-up community-based interventions for people experiencing homelessness; people in custody and for families residing in areas of high social deprivation. The final four papers will report on the implementation and evaluation of social or community-based interventions. This collection of research papers will highlight the importance of focusing on prevention and the adoption of a common risk factor agenda to tackle oral health, health and psychosocial inequities felt by those most excluded in our societies

Iron Catalyzed Double Bond Isomerization:Evidence for an FeI/FeIII Catalytic Cycle

Iron‐catalyzed isomerization of alkenes is reported using an iron(II) β‐diketiminate pre‐catalyst. The reaction proceeds with a catalytic amount of a hydride source, such as pinacol borane (HBpin) or ammonia borane (H3N⋅BH3). Reactivity with both allyl arenes and aliphatic alkenes has been studied. The catalytic mechanism was investigated by a variety of means, including deuteration studies, Density Functional Theory (DFT) and Electron Paramagnetic Resonance (EPR) spectroscopy. The data obtained support a pre‐catalyst activation step that gives access to an η2‐coordinated alkene FeI complex, followed by oxidative addition of the alkene to give an FeIII intermediate, which then undergoes reductive elimination to allow release of the isomerization product

Limits of agricultural greenhouse gas calculators to predict soil N2O and CH4 fluxes in tropical agriculture

Acknowledgements This work was undertaken as part of the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS), which is a strategic partnership of CGIAR and Future Earth. This research was carried out with funding by the European Union (EU) and with technical support from the International Fund for Agricultural Development (IFAD). The UN FAO Mitigation of Climate Change in Agriculture (MICCA) Programme funded data collection in Kenya and Tanzania. The views expressed in the document cannot be taken to reflect the official opinions of CGIAR, Future Earth, or donors. We thank Louis Bockel of the UN FAO Agricultural Development Economics Division (ESA) for his comments on an earlier draft of the manuscript.Peer reviewedPublisher PD

Limits of agricultural greenhouse gas calculators to predict soil N\u3csub\u3e2\u3c/sub\u3eO and CH\u3csub\u3e4\u3c/sub\u3e fluxes in tropical agriculture

Demand for tools to rapidly assess greenhouse gas impacts from policy and technological change in the agricultural sector has catalyzed the development of \u27 GHG calculators\u27-simple accounting approaches that use a mix of emission factors and empirical models to calculate GHG emissions with minimal input data. GHG calculators, however, rely on models calibrated from measurements conducted overwhelmingly under temperate, developed country conditions. Here we show that GHG calculators may poorly estimate emissions in tropical developing countries by comparing calculator predictions against measurements from Africa, Asia, and Latin America. Estimates based on GHG calculators were greater than measurements in 70% of the cases, exceeding twice the measured flux nearly half the time. For 41% of the comparisons, calculators incorrectly predicted whether emissions would increase or decrease with a change in management. These results raise concerns about applying GHG calculators to tropical farming systems and emphasize the need to broaden the scope of the underlying data

Family satisfaction with critical care in the UK: a multicentre cohort study.

OBJECTIVE: To assess family satisfaction with intensive care units (ICUs) in the UK using the Family Satisfaction in the Intensive Care Unit 24-item (FS-ICU-24) questionnaire, and to investigate how characteristics of patients and their family members impact on family satisfaction. DESIGN: Prospective cohort study nested within a national clinical audit database. SETTING: Stratified, random sample of 20 adult general ICUs participating in the Intensive Care National Audit & Research Centre Case Mix Programme. PARTICIPANTS: Family members of patients staying at least 24 hours in ICU were recruited between May 2013 and June 2014. INTERVENTIONS: Consenting family members were sent a postal questionnaire 3 weeks after the patient died or was discharged from ICU. Up to four family members were recruited per patient. MAIN OUTCOME MEASURES: Family satisfaction was measured using the FS-ICU-24 questionnaire. MAIN RESULTS: A total of 12 346 family members of 6380 patients were recruited and 7173 (58%) family members of 4615 patients returned a completed questionnaire. Overall and domain-specific family satisfaction scores were high (mean overall family satisfaction 80, satisfaction with care 83, satisfaction with information 76 and satisfaction with decision-making 73 out of 100) but varied significantly across adult general ICUs studied and by whether the patient survived ICU. For family members of ICU survivors, characteristics of both the family member (age, ethnicity, relationship to patient (next-of-kin and/or lived with patient) and visit frequency) and the patient (acute severity of illness and receipt of invasive mechanical ventilation) were significant determinants of family satisfaction, whereas, for family members of ICU non-survivors, only patient characteristics (age, acute severity of illness and duration of stay) were significant. CONCLUSIONS: Overall family satisfaction in UK adult general ICUs was high but varied significantly. Adjustment for differences in family member/patient characteristics is important to avoid falsely identifying ICUs as statistical outliers. TRIAL REGISTRATION NUMBER: ISRCTN47363549

Lineage replacement and evolution captured by 3 years of the United Kingdom Coronavirus (COVID-19) Infection Survey

The Office for National Statistics Coronavirus (COVID-19) Infection Survey (ONS-CIS) is the largest surveillance study of SARS-CoV-2 positivity in the community, and collected data on the United Kingdom (UK) epidemic from April 2020 until March 2023 before being paused. Here, we report on the epidemiological and evolutionary dynamics of SARS-CoV-2 determined by analysing the sequenced samples collected by the ONS-CIS during this period. We observed a series of sweeps or partial sweeps, with each sweeping lineage having a distinct growth advantage compared to their predecessors, although this was also accompanied by a gradual fall in average viral burdens from June 2021 to March 2023. The sweeps also generated an alternating pattern in which most samples had either S-gene target failure (SGTF) or non-SGTF over time. Evolution was characterized by steadily increasing divergence and diversity within lineages, but with step increases in divergence associated with each sweeping major lineage. This led to a faster overall rate of evolution when measured at the between-lineage level compared to within lineages, and fluctuating levels of diversity. These observations highlight the value of viral sequencing integrated into community surveillance studies to monitor the viral epidemiology and evolution of SARS-CoV-2, and potentially other pathogens

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000

BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors. METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires. DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research